非侵入式可穿戴人体健康指标动态监测仪

随着全球人口老龄化及慢性病管理需求的持续增长,非侵入式可穿戴健康监测设备正迎来爆发式增长机遇(从传统医疗器械向消费电子方向发展)。团队拥有非侵入式组织液无感提取、柔性表皮电化学高精度传感和个性化AI校正三大核心技术,可非侵入式动态监测人体组织液中的关键生物标志物,包括葡萄糖、乳酸和电解质(钠离子、钾离子、钙离子等)等,其中葡萄糖和乳酸浓度通过特定AI算法推算对应血糖和血乳酸水平,实现对多项人体健康指标的非侵入式连续监测。

基于相关研究,团队正努力开发和落地非侵入式可穿戴动态血糖监测仪、血乳酸监测仪和电解质监测仪等三大产品,拟形成的产品形态如图所示,采用“柔性表皮传感器+微型电子检测器+智能手机APP”三位一体架构,传感器贴片可替换,检测器负责信号采集、处理与蓝牙传输,APP实现数据可视化、健康趋势分析和预警功能。

研究内容:

  1. 1.非侵入式动态血糖监测仪

开发高稳定性组织液葡萄糖非侵入式无感提取技术、高稳定性低浓度葡萄糖表皮高精度传感器和个性化AI无采血校正算法,研制医疗级精度非侵入式动态血糖仪,取得医疗器械许可证并落地转化,服务糖尿病人群以及关心饮食、运动等影响血糖变化的健康管理人群。

  1. 2.非侵入式动态血乳酸监测仪

开发基于竞争调控的组织液乳酸非侵入式无感提取技术、高稳定性低浓度乳酸表皮高精度传感器和“提取乳酸-组织液乳酸-血乳酸”多级传递模型及算法,研制非侵入式动态血乳酸仪,服务于运动训练、军事体能监测、医院ICU/急诊等多个场景。

  1. 3.非侵入式动态电解质监测仪

开发非侵入式组织液电解质快速无感提取技术、阵列化表皮离子传感器和运动状态推测AI算法,研制非侵入式动态电解质监测仪,服务于运动医学、航天医学等领域。

参考文献:

[1] Wangwang Zhu#, Chengcheng Li#, Wenjun Li#, Yuxiao Ma, Xingguo Zhang, Hao Zheng, Mingzhen Li, Zhenqiang Song, Dachao Li and Zhihua Pu*, A highly-catalytic hydrogel modified biosensor for wearable and non-invasive glucose monitoring via reverse iontophoresis, Biosensors and Bioelectronics, 2026, 312: 119071.

[2] Wangwang Zhu#, Xi Li#, Jiaqi Hou, Wenjun Li, Jingyun Li, Hao Zheng, Dachao Li and Zhihua Pu*, Personalized non-invasive continuous glucose monitoring via multiparameter-informed machine learning, Biosensors and Bioelectronics, 2026, 310: 118874.

[3]Wangwang Zhu, Haixia Yu, Wenjun Li, Xi Li, Hao Zheng, Chengcheng Li, Xingguo Zhang, Chenxi Jin, Mutian Wang, Jiaqi Hou, Youhao Liu, Yuxiao Ma, Zhongxu Zhou, Miao Deng, Peng Guo, Mingzhen Li, Zhenqiang Song, Zhihua Pu* and Dachao Li*, pH calibration allows accurate glucose detection in interstitial fluid via reverse iontophoresis, Nature Communications, 2025, 16: 10413.

[4] Chenxi Jin, Peng Guo, Wenjun Li, Wangwang Zhu, Chengcheng Li, Jing Ma, Jun Li, Dachao Li, Jing He* and Zhihua Pu*, A wearable self-aid microneedle chip based on actively transdermal delivery of epinephrine, Microsystems & Nanoengineering, 2025, 11: 92.

[5]Zhongxu Zhou, Wangwang Zhu, Hao Zheng, Wenjun Li, Chenxi Jin, Youhao Liu, Dachao Li, Xingguo Zhang* and Zhihua Pu*, Controllable electrode printing on porous hydrophobic substrate for breathable epidermal biosensors, Sensors and Actuators B: Chemical, 2025, 442: 138187.

[6]Wenjun Li, Liangya Han, Dachao Li and Zhihua Pu*, High-frequency ultrasound based microfluidic chip for high-sensitive and quick-response electrochemical biosensing, Sensors and Actuators: B. Chemical, 2025, 427: 137204.

[7] Xingguo Zhang, Zhihua Pu*, Wangwang Zhu, Wenjun Li, Hao Zheng, Chengcheng Li, Dachao Li*, Wide-linearity flexible OFET biosensors for wearable biomarkers detection, Talanta, 2025, 295: 128294.

[8] Wangwang Zhu, Haixia Yu, Zhihua Pu*, Zijing Guo, Hao Zheng, Chengcheng Li, Xingguo Zhang, Jun Li, Dachao Li, Effect of interstitial fluid pH on transdermal glucose extraction by reverse iontophoresis, Biosensors and Bioelectronics, 2023,235:115406.

[9] Hao Zheng, Zhihua Pu*, Hao Wu, Chengcheng Li, Xingguo Zhang and Dachao Li*, Reverse iontophoresis with the development of flexible electronics: A review, Biosensors and Bioelectronics, 2023, 223: 115036.

[10] Zhihua Pu, Xingguo Zhang, Haixia Yu, Jiaan Tu, Hailong Chen, Yuncong Liu, Xiao Su, Ridong Wang, Lei Zhang, Dachao Li*, A thermal activated and differential self-calibrated flexible epidermal biomicrofluidic device for wearable accurate blood glucose monitoring, Science Advances, 2021, 7(5): eabd0199.